Md anderson cancer prevention center

If you notice a decrease in the performance of your car, it's important to address the issue promptly to prevent further damage and ensure your safety on the road.

• Take your car to the nearest car service center and get the basic components in your car like air filter, spark plugs and fuel system completely inspected
• Perform regular maintenance needed for your vehicle
• If you are unable to diagnose the problem on your own or if the error codes are unclear, it's best to consult a qualified mechanic or take your car to a trusted repair shop.

I am glad Creed III went over as well as it did, but if they were to leave it here, I would find it to be an unsatisfactory conclusion to the trilogy. It tried to offer a resolution, but I think it left a lot more elephants in the room and dangling threads of plot that should be addressed in Creed IV. The most obvious one is of course the question of where is Rocky and in my opinion, his presence is still needed in the story for a true final outing to happen. But there’s also the matter of Adonis Creed’s siblings and why they disowned him as well as Bianca’s hearing and when she will finally go deaf.
I would love to hear what suggestions this community has for the synopsis of Creed IV with these plot points in mind. I personally think Creed IV should be a story about Adonis Creed’s struggle with becoming an aging fighter like Rocky IV touched on. Creed III established that Adonis may have retired prematurely to preserve his health and possibly out of respect for his wife with his child in the picture, but it hints that he was never fully satisfied with this decision and the ending even suggests that he longs to reclaim his place in the ring. I think a logical stepping stool would be for Adonis to enter his mid-life crisis Apollo in Rocky IV phase where he is afraid of fading into obscurity or irrelevance and he wonders if he did enough to cement his legacy as a fighter.
With the plot point about Adonis’ beef with his siblings in mind, I think an interesting dynamic would be for Adonis to be on horrible terms with them growing up because in their mind, he ruins the good name of their father since he is the product of his infidelity and subsequently became all Mary Anne could focus on, which would lead to bitterness and resentment on their behalf. So I was thinking what if Adonis Creed’s half brother has a child in his 20s who is inspired to be a heavyweight champion like his grandfather, but he’s poisoned against Adonis Creed by his father because he always hated him in adulthood for stealing their mother away from them and in their minds, soiling Apollo’s legacy by being an illegitimate Creed who capitalized on the namesake. This would all tie back into Adonis Creed’s issue in the first Creed of inheriting the name.
I would write it to where Adonis Creed’s half brother blew his whole inheritance and has an alcohol addiction because when his father died, he grew up into a irresponsible adult who fell behind in life and started to make bad decisions, which would explain his absence in the trilogy. His son, of course, inherits all of this trauma and is mad as hell at the world, which means he also has a huge chip on his shoulder at Adonis for being the successful Creed son and feeling like he hasn’t earned it.
I would want Adonis to patch things up with his half sister in adulthood who will explain how her brother never had the heart he did to achieve something greater in life and now he’s given his burdens to his son.
At first, Adonis wouldn’t want to take the fight because he doesn’t want to fight his nephew, but his nephew wants to restore honor to the Creed name by beating him and becoming the “true” successor to Apollo’s legacy.
In the midst of this, I would want Bianca to get a prognosis from a doctor that she may have a form of cancer in her ears and I want this to take a heavy toll on Adonis’ emotional state that makes him reflect on his time taking care of Rocky when he was sick, which leads to them finally reconnecting after years of not seeing each other. Adonis will finally have the opportunity to empathize more fully with Rocky about the passing of his wife. Rocky will agree to train Adonis for one last fight against his nephew. I think a scene where Logan and Amara meet and become friends would sweet, too.
I want the fight to be hostile and intense with the resentment towards Adonis on full display. Apollo’s grandson should be unapologetic about his disdain for him to show the influence his father had over him.
In essence, I want the story to be a combination of all three Creed movies into one pot. The legacy theme of the first with an antagonist who is basically a combination of Viktor Drago and Damian Anderson.

One thing that recently hit me is that the Arrancar don't have a proper faction symbol. The Gotei have, like, over thirty different symbols and emblems of the overall organisation, squad specifics, you could even count the Substitute Shinigami badge skull too. The Quincy and Wandenreich have variations of the five-pointed cross/star motif to varying degrees of complexity. Heck, even the secret Xcution group have a stylized logo for their business cards. The Arrancar, Hollows, and by extension Aizen and Co., ... nothing.
Granted, this can be explained because of the lore. Barragan may not have seen the point of a symbol for him out of sheer arrogance. He didn't have a roof because the sky was his, he didn't have walls because his domain stretched on forever, so why would he need a symbol if his status as the one and only power in Hueco Mundo was absolute? Aizen saw his Arrancar as useful soldiers at best and disposible bodies at worst; they existed only to further his goals, not to form any long-lasting organisation. Why bother making a symbol for something so temporary and disposable? As for the post-Aizen ruler(s), Harribel didn't want the job of queen and mostly took over to prevent disorder and protect the ones she cared about, ditto for Nel, and Grimmjow doesn't immediately strike me as a guy who values symbols and emblems (beyond his 6 tattoo).
However, I highly doubt I'm alone in liking Bleach's various symbols ascribed to individuals and organisations. So, back to the post title, if we were to give each phase of Hueco Mundo leadership a faction symbol, what would they be?I'll start us off with my ideas (note all of these are in black with a white background as most faction symbols are in Bleach):

1. Barragan era: I see three definitive choices for inspiration for him; his skull mask, his old crown, and axe Gran Caída. His skull with it's distinctive scar, a stylized version of his crown, or even a combination of the two would work well. What could be more fitting and ego stroking that the very face of the god-king himself? A simplified form of Gran Caída, an axe with chains around it could also work as a symbol of his power (the axe) and the servant status of all Hollows under him (the chains). That jewelry piece in the shape of an eye he wears in his Ressurection could also work, but I'm not sure if he had that as a hollow.
2. Aizen era: I can't think of anything more symbolic to Aizen and his rule over Hueco Mundo than the Hōgyoku. To the Hollows, it was a safe and sure means to achieve power and stability as fully realised Arrancar; to Aizen it was his key to ascend beyond all others and facilitate his future plans as Soul King. An insignia based around the Hōgyoku makes sense; I'm thinking a black octagon outline with a black circle in the middle to represent the seal around the orb and the orb itself. Could also nicely contrast with the Gotei squad insignias which use a black outlined square with the squad number in the middle.
3. Post-Aizen era: This is the one I'm struggling with the most; with Harribel, Nel, and Grimmjow in control, finding a symbol that all would be happy with and unites them is tricky. They all have various things that could work as symbols for themselves, but not as a whole. My best guess would be something representing Hueco Mundo; maybe a simplified picture of Las Noches, either from the side or above, or a quartz tree. Or perhaps something representing Hollows in general, and for that most uniform image of Hollow-ness would be a Gillian. So perhaps a black, upright oval or rounded tall triangle with white circles at the top and center to represent the mask and hollow hole, respectively.

Thoughts on my ideas? Ideas of your own? Please comment below.

Hello everyone,
Last January, I purchased a CX-60. As it is still difficult to find user reviews of this model, I took the time to write this review in the hope that it can be helpful to you if you are considering buying this car. I hope that my experience can answer some of your questions and assist you in your decision-making process.
Exterior Design (4/5)
The design is particularly successful. The car has a sleek look and gives the impression of being in motion even when stationary, just as the designers promised during the design phase. It has nothing to envy compared to its competitors, such as the Audi Q5. Although I'm not a big fan of black rims, I must admit that they blend harmoniously with the Takumi package on this model. The black accents on the rims, tinted windows, and mirrors create a visual signature that doesn't go unnoticed. Unlike most models, it stands out more in person than in photos, especially in terms of size. It is truly massive. For comparison, it is longer and taller than an Audi Q5. When you see it for the first time, the "wow" effect is guaranteed. However, the rear of the vehicle is less expressive and does not do justice to the front and side views. Fortunately, the quad exhaust at the back helps maintain the sporty character of the model.
Interior Design (5/5)
The interior layout is clean, simple, and modern. It features a large central screen, a minimally customizable driver display, and a head-up display integrated directly on the windshield. This efficiency will surely appeal to those who struggle with screens everywhere displaying unnecessary information. Similarly, you cannot customize the ambient lighting in the evening. The lights are fixed, in a neutral color, and the adjustment only offers 3 intensities. It may not be to everyone's liking, but personally, I find it liberating to be free from countless customization possibilities that always leave a sense of dissatisfaction. As for the materials, they come in understated colors and durable textures, both in terms of aesthetics and longevity (at least for now, time will tell). The center console is impressively wide and gives a sense of space rarely felt in vehicles of similar size. When driving this car, you feel like you're aboard a large American SUV like the Suburban or Ford Explorer. Unfortunately, there are not many storage compartments. The huge center console only offers a tiny compartment that can hold a few small items and keys at most. The door pockets are also very low and not very practical.
Ergonomics (4/5)
The cabin offers generous space for all occupants, including the rear seats where even adults over 1.80m tall have ample legroom. The seats, which are rather firm and have limited adjustments, can be surprising at first, especially if you're coming from a vehicle with a multitude of settings. In the first few days, I experienced sharp back pain, especially since the car lacks flexibility as I'll mention later. After three weeks of adjustment, the pain disappeared, and I even noticed an improvement in my posture. In my previous vehicle, my seat was so comfortable, like a sofa, but now I realize it was bad for my back. Inside this car, with its comfort inspired by Japanese tatami mats, I ultimately feel better, less slouched, and more alert. The trunk offers significant capacity, especially compared to similar models. However, it doesn't have a dual compartment or a sub-trunk to store charging cables. The tailgate rises very high, over 3 meters. It struggles to lock in place when encountering resistance, which can damage it from the first uses. I recommend adjusting it by pressing the closing button while it's opening, to lock it at the desired height, and holding down that button for 5 seconds (until you hear a series of beeps) to limit the opening range.
Technologies and Equipment (3/5)
The connectivity is quite comprehensive, although Apple CarPlay suffers from some instability and unexplained bugs (random disconnections, unexpected cuts, slowdowns, random automatic connection). Wireless charging also sometimes poses a problem. It works randomly and seems to generate a lot of heat on the phone. When not in use, an error message keeps flashing, indicating that no phone is being charged.
As for driving aids, the lane-keeping system works very well, although it is not autonomous. If you don't have your hands on the wheel, the car behaves like a billiard ball, bouncing from one lane to another. However, if it deviates from its trajectory because you're not attentive enough, it will alert you and secure the car by making a steering correction. It's very reassuring and always activated at the right time. Moreover, it's even a valuable aid on high-speed winding turns, on certain departmental roads. Other vehicles end up cutting through the turns or having to slow down excessively, while you effortlessly stay precisely in your lane.
I was very disappointed with the cruise control, which is not adaptive. Later, I discovered that it is an option that is disabled in the software since all the necessary sensors are already present. You can confirm this through ActiveSense, which provides a complete view of surrounding vehicles. So, I wanted to add this option later, willing to bear the cost, but Mazda doesn't allow it. This strategy, or lack of a sales strategy, is surprising.
The temperature management inside the car is surprising. Without changing the temperature settings in automatic mode, during a long drive, there is a yo-yo effect that is difficult to explain. One moment, it feels quite cool, and a few minutes later, it becomes too hot. I wonder if it's related to the external brightness because on a hot spring day, the air conditioning temperature suddenly rose when the sky suddenly became overcast. However, it was still hot outside. I think there's an overly reactive adaptive mode at play.
The remote car management is quite good. It's possible to activate the heating or air conditioning, which will run for a maximum of 30 minutes before shutting off and sending a notification to your phone. You can extend it if you have a good signal. The car surprisingly receives a signal in unexpected places, even in underground parking lots where my phone has no network. This remote temperature mode is ideal for defrosting the car or leaving a dog inside during cold weather or in the summer when the temperature rises quickly in a closed and parked car. I've tested it in extreme cold and hot seasonal temperatures, and it works very well so far. Of course, it consumes a lot of energy, but you can't have everything without a trade-off. It's suitable for occasional use. The rest of the remote features include locking the car, checking tire pressure, consulting the range, and receiving alerts if the alarm is triggered, which is very reassuring. It's also possible to locate the car precisely. It's a shame that we can't access the cameras, as in other fully electric models.
It's not clear in the vehicle manual, but to deactivate the alarm, you need to press the alarm button on the remote right after locking the car. The indicator will blink 4 times, and then it will be turned off. It's better to do it before leaving your dog alone, or else the alarm will be triggered if the dog moves inside the vehicle.
Performance and Driving Dynamics (4/5)
I own the 327-horsepower PHEV model: 200 horsepower from the atmospheric gasoline engine and 127 horsepower from the electric motor. Although the low-end power is reduced with an atmospheric engine, the electric motor more than makes up for it with its responsiveness and instant torque. Despite its weight, the car is very agile. It even outperforms some more powerful or lighter petrol-powered cars in terms of acceleration. Of course, such models regain the advantage in corners, but not in straight lines. The acceleration is impressive, although the road noise insulation somewhat dampens the sensation. Other vehicles seem almost stationary when you step on the accelerator.
I was initially disappointed with the braking performance, which was less impressive than in my previous vehicle. However, by pressing the pedal harder and adjusting the regenerative braking to the maximum, I managed to get used to it.
The handling is remarkable. Although it's not a sports car capable of maintaining very high speeds in corners, it still surpasses similar-sized competing models. Thanks to the four-wheel drive and four-wheel steering, the turning angle and trajectory in corners are impressive for a car of this size. One of the drawbacks of the vehicle lies in the stiffness of the suspension. Despite the excellent noise isolation, you feel the road imperfections more than you would expect when driving an SUV. Even at low speeds, speed bumps are very uncomfortable and cause items in the trunk to bounce around. Mazda seems to have made this choice to prevent the relatively high car from swaying in corners and reduce the risk of rollovers at high speeds. Adaptive suspension could have solved this problem. However, considering the pricing position against the competition, I understand why the brand overlooked this aspect. Moreover, after 3000 km, I noticed that the suspension has become slightly softer, improving comfort to some extent.
Energy Efficiency and Range (2/5)
The consumption and hybridization aspects encompass the majority of the vehicle's drawbacks. The car discharges quickly, and the actual range is much lower than what the manufacturer claims. Like many owners, I also face a discharge issue when the car is parked. It loses about 30% of charge in 24 hours (and even drains the 12-volt starter battery - as if the headlights were left on). This problem is due to software that prevents the car from entering sleep mode. I have already taken my vehicle to Mazda for reprogramming, and I will have to do it again soon because the issue is still unresolved (now I lose 15% in 24 hours). This problem is not part of the manufacturer's recalls, but many owners are affected. Dealing with a less established manufacturer, this can quickly become a headache. I had to go through many steps and cancel orders for other CX-60s for my company before being taken into consideration by the after-sales service. During my third call, Mazda France assistance even replied to me that they are not Audi. The message is quite clear.
Beyond this specific issue, the management of hybridization lacks customization and seems suitable for a specific use case only. If you live in a house, always have the car plugged in, and regularly make short trips, this plug-in hybrid is suitable. However, if you cannot plug it in daily or if you regularly drive more than 50 km round trip, you might be disappointed. Especially considering the consumption of this car in electric mode, it is often more expensive to charge it than to refuel with gasoline. The cost per 100 km is 2 to 4 times higher at current energy prices. Personally, I opted for the hybrid due to the tax incentives and benefits, but I also wanted to take advantage of remote heating and air conditioning options, especially when I have to leave my dog in the car for a few minutes. Since I cannot recharge it daily in the parking lot of my building, it would be desirable to be able to keep a charged battery and drive in combustion engine mode, but no mode truly allows that. It is possible to choose to recharge the car while driving, consuming approximately 13 liters per 100 km, but you cannot choose to drive solely on the combustion engine without using the high-capacity battery. The sport mode comes close, but the gears are shifted at high RPM, making the driving experience jerky and particularly noisy, and the battery is used as soon as you accelerate a bit (to activate the 137-horsepower motor). An exclusively combustion engine mode would have been relevant, similar to the exclusively electric mode. Furthermore, recharging the battery while driving doesn't work correctly. The recharge is very fast, much faster than when it's connected to 7 kW chargers. However, the displayed percentage does not correspond to the actual charge, which explains why it continues to recharge beyond the set percentage. For example, if you're at 30% and ask the car to recharge up to 50% while driving, it will work at a high rate until it reaches 50%. In normal mode, it will stop recharging the battery, but will continue operating at a high rate to not drop below 50%. So, you end up consuming more without reason, with the engine noise constantly high, which is quite unpleasant. In sport mode, it will continue recharging the battery above 50% without any limit. However, once the car is stopped and restarted, you'll notice that you weren't at 50%, but rather at 35%. The fast recharge was, therefore, fictitious. The problem is that this is a first for Mazda in terms of technology, and no one there is able to provide answers on this matter. The garage I visit explains that Mazda is highly centralized and communicates very little in terms of engineering with the garages. It is, therefore, common for a problem to persist for several months (or more) before being addressed at the technical management level in Japan and then transmitted to local dealerships. However, when deciding to market a technologically immature car, it would be wise to establish a continuous improvement process based on user feedback. In fact, on forums, we can see that Japanese users receive preferential treatment compared to the rest of the world. In conclusion, the battery of this car, which needs to be recharged at a high cost, is only useful for the first 40 kilometers. So, you spend over 3 hours recharging a battery at an exorbitant rate for only 25 or 30 minutes of driving without using gasoline. One might wonder if it's simply a trick to equip professionals, allowing them to benefit from incentives and reduced tax on company vehicles (the primary reason for my purchase). I think many people will never plug it in.
Cost and Value for Money (4/5)
The value for money of this model is indeed very interesting when compared to vehicles of the same standing from other brands, such as Audi. For example, an Audi Q5 offers a similar level but with an additional cost of €25,000. For the same price as a Mazda CX-60, you would only get a Q3 from Audi, which is clearly not comparable. However, it is important to note that the depreciation of this vehicle could be significant, and it might even become difficult to resell it in a few years. This is also true for all plug-in hybrid models. Therefore, I would recommend this model, provided that you negotiate the price well or opt for a lease (the offers are very attractive, and personally, I chose this payment method). The PHEV configuration of the vehicle is suitable for individuals who have daily access to a charging point and have diverse travel needs, ranging from short to long trips. Before the increase in electricity prices, the cost per 100 km was slightly more advantageous compared to gasoline, but today it is the opposite (except when charging from a domestic socket).
Conclusion
I am delighted with this car considering the price at which I acquired it. The positioning is unbeatable, and there are good deals to be made to drive this luxury sports SUV at the price of a "regular" SUV. With a domestic electric socket, choosing the plug-in hybrid is a good middle ground. It's just a shame that the hybrid management is not more refined. Perhaps future updates will address these teething problems.

Layout:
— Individual Team News + Stone’s Cold Takes
— Miscellaneous/Other NFL News
— Restaurant of the Week - Washington D.C.
Arizona Cardinals:

• Released WR DeAndre Hopkins and he listed out info about what he wants in his next team:
  
  • Josh Allen, Jalen Hurts, Patrick Mahomes, Lamar Jackson, Justin Herbert
  • He wants stable management and a great defense
• Some folks in AZ were upset with Hopkins because he sat out the last couple of games
  
• S Budda Baker says he will be at camp when its time for him to be there
  

After some decent news the last couple weeks for this organization there wasn’t really anything great from this week besides maybe the fact that if WR DeAndre Hopkins was a distraction to the team he now no longer is one. It will be interesting to see how things play out this year.
Atlanta Falcons:

• FB Keith Smith was arrested on traffic charges
  
  • Driving with a suspended license he claims was a misunderstanding
• K Younghoe Koo didn’t ask for money from RB Bijan Robinson to give him his number but asked him to pick a charity at some point down the road to donate to
  
• Will have joint practices with the Dolphins
  
• Signed:
  
  • WR JJ Arcega-Whiteside

It sounds like the situation with Keith Smith should get resolved rather quickly and was more of a misunderstanding than anything else. It will be fun for this young team to have joint practices with Miami and it will be a good way for their defense to get an initial test from an elite offense. I am sure the Dolphins won’t reveal all of their tricks but either way they will have to worry about guarding an elite offense with elite playmakers.
Baltimore Ravens:

• QB Lamar Jackson expects a more pass-heavy offense under new OC Todd Monken
• WR Michael Thomas separate his shoulder and could require labrum surgery
• WR Rashod Bateman who just played just 6 games was on the field for OTAs on Monday
• Waived Daelin Hayes
• S Kyle Hamilton excited for expanded role with the team
• Tony Jefferson is retiring and joining the team as a scout
• Signed:
  
  • DL Angelo Blackson
  • QB Josh Johnson

It is crazy to think about how just about a month ago the news around the Ravens was all negative and that it seemed like the relationship with Lamar was fractured. Now here we are and Lamar seems about as happy as can be and is excited about the offense that is being installed under new OC Todd Monken. It will be exciting for him as well to have WR Rashod Bateman back who I still think can be a key playmaker on the team. It appears the Ravens could be set for big things even in a tough division.
Buffalo Bills:

• No surprise, QB Josh Allen is hyper-focused and wants to win a Super Bowl
• S Damar Hamlin is back out working out on the field
• WR Stefon Diggs did not attend OTAs
• EDGE Von Miller guarantees he will play by week 6 but is not rushing anything
• Signed:
  
  • S Dean Marlowe
  • Joel Wilson

Great to see the that S Damar Hamlin was back out practicing. I know it has been some time since his collapse on the field but it still feels like yesterday that I was watching that game in complete shock at what I had witnessed and worry for him and his family. WR Stefon Diggs being absent at OTAs is not a big deal to me. QB Josh Allen has a lot of other guys he needs to get familiar and work in with anyways and a lot of star players don’t attend OTAs to either get rest/recovery or to do their own workouts with their private coaches. I imagine he and Kincaid will be deadly this year and who knows they may even have WR DeAndre Hopkins joining them as the Bills were one of two teams that inquired and had talks about a trade for him.
Carolina Panthers:

• TE Hayden Hurst is recovering from sports hernia surgery
• QB Bryce Young is taking most of the first team reps

Not too much news here other than what we saw and heard from OTAs about Bryce Young getting to take most of the 1st team reps. It appears that he looked good and his teammates were saying great things about him. It is tough to judge any quarterback though in the offseason because no matter what folks always say their young or new quarterback is looking amazing and things are progressing nicely. I will say though I have heard the most good things coming out from camps about him and Anthony Richardson of the Colts.
Chicago Bears:

• QB Justin Fields excited about the growth WR Chase Claypool had over offseason
• Got permission to begin demolition of Arlington Park racetrack

Good news for Chicago fans who are excited for their move. It seems that things are proceeding nicely with the process of moving to a new stadium. Also, great to hear that Chase Claypool may be able to make more of a difference this year. It would be hard to be less effective than what he was last year for this team. I still believe he can be a major impact player like many expected him to be when he entered the league. It will be key for him to become Fields’ go to receiver over some of the other talent they have on the team.
Cincinnati Bengals:

• Want to sign WR Tee Higgins and LB Logan Wilson to long term extensions
• Have made their initial push for QB Joe Burrow

This team has a lot to do in terms of contracts that they need to get figured out. The team view Tee Higgins in very high regard and so does Joe Burrow as they should. They also really want to get Logan Wilson signed. However, what will come out to being the biggest of the contracts they do this offseason is that of Joe Burrow. What will continue to make things tough here is the longer it takes for Justin Hebert to get his deal done because Burrow will likely be the last of the 4 quarterbacks to sign his because it is presumed he will get the most money and has an agent who like to wait til the last minute.
Cleveland Browns:

• WR Elijah Moore feels good now that he feels wanted with his new team
• EDGE Za’Darius Smith is excited to be facing the Ravens this year

All good news for Browns fans so far. The team is looking good and their appears to be a lot of good vibes coming out of practice. WR DeAndre Hopkins is even considering coming to Cleveland for the chance to play with his old QB. Also, WR Elijah Moore is looking crisp and at least for the moment it appears he is much happier. It will all depend on if he actually gets the ball thrown to him during the season though.
Dallas Cowboys:

• HC Mike McCarthy is keeping offense in Dak’s language despite the changeup in play callers

Not too much news here which is good for this franchise because they are almost always the center of attention. The main thing I took away from this week was just that things seems to be going well with McCarthy and Dak working together on the offense but that there have been some growing pains at least initially getting used to new systems as expected.
Denver Broncos:

• Waived Hunter Thedford with injury settlement
• Released K Brandon McManus
• K Brett Maher worked out for the team
• QB Russell Wilson has lost a lot of weight this offseason
• HC Sean Payton excited about what S Kareem Jackson can do to help team
• RB Javonte Williams was limited in OTAs starting on Thursday
• Signed:
  
  • T Cam Fleming to a 1-year $4m deal
  • DT Tyler Lancaster

It appeared to shock just about everyone when the news broke about K Brandon McManus getting released because he had become a fan favorite over the years in Denver. QB Russell Wilson has lost a lot of weight and it is evident just from seeing him this offseason. I didn’t think his weight was the issue hindering him last year but hopefully he can feel he is playing at a healthier weight. What I think most Denver fans were excited to see was RB Javonte Williams back on the practice field. He is going to end up being the real difference maker this year and whether this team competes with the top of the AFC or not will largely depend on him making the rest of the offense’s life easy or not.
Detroit Lions:

• Former WR Calvin Johnson was at OTAs this week after having been away from the organization following a rough falling out post-retirement
• RB David Montgomery said that losing with the Bears “sucked the fun out of the game”
• WR Jameson Williams says that he didn’t know about the gambling policy; HC Dan Campbell feels he is miles ahead in terms of his talent already
• Traded an undisclosed draft pick for K Riley Patterson
  
  • Signed a 1-year $2.35m deal
• RB David Montgomery and LB Malcolm Rodriguez left practice due to injury
  
• Team has done their homework on free agent WR DeAndre Hopkins
  
• NFL is investigation another Lions player about league gambling rules violations
  
• Signed:
  
  • OL Germain Ifedi
  • Max Pircher through international player pathway program

A lot of news here. Let’s start with the bad news. It appears that they may be having more penalties come down on their team/players due to the league’s gambling policy as their is an ongoing investigation into a 5th player from the team. Also, David Montgomery and Malcolm Rodriguez left the field with injuries. It is still early though and they appear to be minor injuries so hopefully it won’t affect them in the long term. Now some good news. It sounds like WR Jameson Williams is progressing nicely and the team got a new kicker in Riley Patterson from the Jaguars who should help the improve there. Lastly and maybe the biggest news is that Calvin “Megatron” Johnson was at OTAs hanging out with coaches and players. Many are hoping those good vibes carry over into the season.
Green Bay Packers:

• Signed:
  
  • WR Jadakis Bonds
• Cut TE Nick Guggemos
  
• Will host the 2025 NFL Draft
  
• HC Matt LaFleur is please with Jordan Love but still need to work on a lot of things
  

Exciting news that Green Bay will get the draft in 2025! I was thinking they would try and stick to more southern states but they clearly are willing to go North with Detroit and now Green Bay being the hosts of the next two. HC Matt LaFleur appears to be being honest with everything and trying to temper expectations a bit with Jordan Love taking over. This could be to help take pressure off of Love and also just be the flat out truth that with any young quarterback it is going to take some time.
Houston Texans:

• Appears DeMeco Ryans may not be too sure about pursuing Jadeveon Clowney
• HC DeMeco Ryans expects the o-line to be a strength for this team
• Currently it is a QB competition between Davis Mills and CJ Stroud
  
  • Other teams have been inquiring about QB Davis Mills

I am not surprised about DeMeco Ryans hesitancy about pursuing Jadeveon Clowney. First of all he just may not want to reveal his cards to others in the league about what he is thinking. The other thing is that he is one that likes for his defense to have an identity and a really good work ethic. I am not saying that Clowney can’t fit that mold but it just makes the selection process for what Ryans wants on defense that much more thorough. The other news that surprised some but something I mentioned a couple of weeks ago is that QB Davis Mills will compete with Stroud for the starting job and is viewed as a desirable QB to other teams around the league. I know his stats haven’t been the best but I am not sure any of the young quarterbacks would have done well with what the Texans organization has been the last couple years. At the end of the day CJ Stroud will end up being the team’s starter due to draft status and probably will be the more talented, better option.
Indianapolis Colts:

• No timetable for Shaquille Leonard to resume practicing
• QB Anthony Richardson was running a similar offense to what Jalen Hurts has run in Philly and was very impressive (splitting 1st team reps)
• Signed:
  
  • TE Kaden Smith

Overall things seems to be good for the organization. The main thing we are all waiting on is when Shaq Leonard will be able to get back out there and start practicing. It makes sense not to have him practicing now since things are optional anyways. The hype has been there for QB Anthony Richardson thus far and it appears he may be closer to starting right away than a lot of people thought.
Jacksonville Jaguars:

• Traded K Riley Patterson to the Lions for an undisclosed draft pick
• RB Travis Etienne looking forward to doing some fine-tuning this year
• Signed Brandon McManus

Not too much news out of Jacksonville other than the change at the kicker position. Things got busy and they were able to trade K Riley Patterson to the Lions rather than release like the reports had said prior. Then they went out and got a proven veteran in K Brandon McManus who had just been released from the Broncos squad. This team is going to be interesting this year and will go as far QB Trevor Lawrence can take them. Does not hurt to have the veteran kicker for the big moments that could be coming for this organization.
Kansas City Chiefs:

• HC Andy Reid is not a fan of the kickoff rule change hinting at the NFL getting closer to being flag football
  
  • TE Travis Kelce is not happy about it either
• QB Patrick Mahomes addressed contract saying he cares more about Super Bowls
  
• LB Nick Bolton doesn’t think the defense gets enough credit
  
• QB Patrick Mahomes says that it has been a smooth transition to new OC Matt Nagy
  
• HC Andy Reid feels fullbacks have been phased out of the NFL and that the Chiefs will not be using one
  

HC Andy Reid who normally is pretty quiet and doesn’t get too involved was in front of the media a lot this week it felt like. First, he is not a fan of the new kickoff rule and it appears most coaches are not. Second, he talked about how the team will not be using a FB because they are being phased out of the NFL and he feels that the TEs they have on the team can play the role when needed. Overall it seems things are going well for the Chiefs and things could be a going a lot better here soon as they appear to be a top option for WR DeAndre Hopkins and one the few teams that had trade talks before he was released.
Las Vegas Raiders:

• Former QB Tom Brady reached an agreement to be a minority owner of the team
• QB Jimmy Garoppolo had to have foot surgery after signing with the team and there is not timetable for his return - believe he should return before the season
  
  • Things could get interesting depending on how situation with Jimmy G works out
• WR Davante Adams is not happy about the current QB situation with the Raiders
  
  • Adams and team have been sued by the photographer he shoved last year
• Will have joint practices with the 49ers
  

It appears there is never a dull week with the Raiders. The news this week about Jimmy seem to add context potentially to what Davante Adams’ comments were about recently. With Tom Brady recently joining the ownership group here it makes us all wonder if the injury is not cleared up is there a way for him to un-retire once again…only time will tell.
Los Angeles Chargers:

• Signed:
  
  • RB Austin Ekeler to a new deal for this final year that added on up to $2m in incentives

Big news here getting the deal done with Austin Ekeler even if it still only keeps him around for 1 year. Thankfully now he should be semi-happy for that one year before he can go out and chase a big contract if he wants to.
Los Angeles Rams:
Not much news here really. Sounds like Matthew Stafford has taken Stetson Bennett under his wing and started to work with him and help him learn more about the transition to the NFL compared to college.
Miami Dolphins:

• WR DK Metcalf challenged WR Tyreek Hill
• Will have joint practices with the Falcons
• QB Tua Tagavailoa is wearing a camera on his helmet to help HC Mike McDaniel see what he sees on the field

I loved seeing Tua wearing the helmet cam. I had not thought about it before but it should be great for him to be able to show McDaniel exactly what he is/was seeing out on the field to add context and allow McDaniel to better coach him and understand what is going on. I think this should be something all quarterbacks do and especially the top ones because it could gives coaches that much more information and a better understanding of how to help young quarterbacks in the future.
Minnesota Vikings:

• Signed:
  
  • WR from the XFL Lucky Jackson
• DC Brian Flores wants defense to develop an aggressive identity but not reckless
  
• RB Dalvin Cook could be a June 1st cut
  

All signs appear to be pointing towards RB Dalvin Cook getting released. In other news it will be good for the defense to develop the aggressive mindset that Brian Flores wants and should bring in the attitude from Miami that wad established during his time there that was so effective and led to them winning games.
New England Patriots:

• Got docked 2 days of OTA workouts for violating offseason rules and HC Bill Belichick was fined $50,000 dollars
• Placed LB Raekwon McMillan on injured reserve due to partially torn ACL

The Patriots seems to always be up to something. It sounds like they were penalized the 2 days of OTAs and fined because of a meeting that Joe Judge held that lasted more than the permitted amount of time. Other tough news came when Raekwon McMillan got injured.
New Orleans Saints:

• TE Foster Moreau is participating in OTAs
• Being in New Orleans has given QB Derek Carr a breath of fresh air
• Former HC Jon Gruden is working with the team and Derek Carr

What a story. TE Foster Moreau finds out he has cancer in a physical with the team a couple months and gets ahead of things and is now practicing with them at OTAs. Interesting story here about former HC Jon Gruden working with the team because during his time with the Raiders many said that he and Carr did not get along. This team has a big opportunity to take over the NFC South and is probably the bet setup to do it with the team they have.
New York Giants:

• Rookie WR Jalin Hyatt wants to get to 190lbs as his playing weight
• TE Darren Waller is happy to somewhere where his opinions are valued
  
  • QB Daniel Jones is enjoying working with TE Darren Waller
• HC Brian Daboll will not speak on contract situations despite currently Barkley situation
  

It seems that everything is going great except the Saquon Barkley situation. There isn’t much new insight into it either after HC Daboll refused to speak on anything contract related. In good news it seems like TE Darren Waller is really enjoying being with the team and working with QB Daniel Jones. This is a team to me that is going to play inspired football like they did last year no matter what is going on because their HC.
New York Jets:

• QB Aaron Rodgers had minor calf strain
• WR Allen Lazard went down during OTAs but supposedly was just a shot to the groin
• Worked out P Matt Araiza
• Chuck Clark was happy to be traded because felt disrespected by the Ravens
• HC Robert Saleh is confident a deal will get done with Quinnen Williams
• Will have joint practices with the Buccaneers

I imagine Jets fans held their breath when they saw Aaron Rodgers get injured as well as Allen Lazard. The good news is that those are not going to be issues in the long run. However, it reminded us all that QB Aaron Rodgers is not a young guy anymore and there is always the possibility that he like any other player in the NFL can get hurt. Hopefully the deal with Quinnen Williams can get done sooner rather than later. I am looking forward to the joint practices with the Bucs because they have a solid defense and it will be fun to hear how they fare in the early phases of implementing a lot of things from both Nathaniel Hackett and Aaron Rodgers.
Philadelphia Eagles:

• OL D.J. Fluker worked out for the Eagles
• DL Jordan Davis has made major strides this offseason will take on a larger role

Jordan Davis is going to be a key piece for the team this year in my opinion so it is great to hear he has made major strides. He is a force to be reckoned with when it comes to his sheer size and the more he can be weaponized the better.
Pittsburgh Steelers:

• Signed:
  
  • EDGE Markus Golden to 1-year deal
  • LB Toby Ndukwe
• Easy decision for QB Mitch Trubisky to sign extension
  
• Started contract talks with OLB Alex Highsmith
  
• Released Tae Crowder
  
• Want to play a regular season game in Ireland
  
• WR Allen Robinson has been very impressed so far by QB Kenny Pickett
  
• QB Kenny Pickett had his car stolen with his playbook inside of it
  

Great move to get Markus Golden. He can be dangerous in this defense and is only one season removed from a double digit sack year. Also, good to see that Robinson and Pickett appear to be getting along. I am curious to see who shakes out to be the #1 receiver on this team but have a feeling it will end up being Pickens because of how good he was last year and the chemistry he and Pickett already have. A QB likes it when his receiver makes life easier and bails him out. Pickens has already done that on multiple occasions for him.
San Francisco 49ers:

• QB Trey Lance just wants a chance to compete and never considered being traded
  
  • Raved about this time working with QB Patrick Mahomes
• QB Brock Purdy expected to start throwing next week, be able to go from gripping a towel to an actual football
  
• QB Sam Darnold will push to start come week 1
  
• Levi’s will officially get the Super Bowl in 2026
  
• LB Dre Greenlaw has a thumb procedure and will miss most of the OTAs this offseason
  
• Will have joint practices with the Raiders
  

It is official the 49ers will host the 2026 Super Bowl! After speculations and rumors it finally became official this past week. Also, there was a lot of good QB news this week with all 3 of the QBs on the roster. Sounds like Brock Purdy is healing properly and as expected, Trey Lance is looking really good in OTAs along with Sam Darnold. Once again this offseason no one is sure who will be starting for the team come week 1.
Seattle Seahawks:

• WR DK Metcalf challenged WR Tyreek Hill
• CB Tariq Woolen had arthroscopic knee surgery and it out til training camp
• Signed:
  
  • CB Artie Burns

Good news for Seahawks fan that Tariq Woolen will be back around training camp time after his procedure. Other than that there was not much news here. They got a solid rotational/depth player in Artie Burns though.
Tampa Bay Buccaneers:

• Video of QB Baker Mayfield making an overthrow went viral on social media
• Will have joint practices with the Jets
• WR Chris Godwin feels like he has a lot of his explosion back
• Team wants to see more consistency out of LB Devin White before offering him the contract he wants

Great to see that Tampa has joint practices with the Jets. They have a tough defense and it will be good for Baker and the offense to get some work against that defense early on. The Bucs have some great weapons on the offensive side of the ball to really compete with those top defenses and if they can all stay healthy this team could be a dark horse team to watch. Overall this should be a good all around team.
Tennessee Titans:

• QB Will Levis is putting pressure on Tannehil and Willis in OTAs this far
• S Kevin Byard is skipping OTAs

Interesting to see that S Kevin Byard was not at OTAs after earlier this offseason it was rumored he was asked to take a pay cut. Definitely a situation to watch. The main news that came from OTAs is that QB Will Levis appears to be looking good and some folks think he could be putting pressure on Tannehill early on and moving himself up the depth chart.
Washington Commanders:

• HC Ron Rivera said that DE Chase Young understands them not picking up his 5th year option
• New OC Eric Bieniemy has been getting on young QB Sam Howell holding him accountable
• Trademark application was denied due to someone else already having pending applications for the name but the team is confident this issue will get resolved
• It has been good for QB Sam Howell that QB Jacoby Brissett has been in the building
• TE Amani Rodgers tore his ACL and is out indefinitely
• Released Nathan Gerry
• Jamin Davis limited in OTAs after knee procedure
• Financing needs to be adjusted in order for the Josh Harris bid to be accepted
• Signed:
  
  • XFL LB Ferrod Gardner

Feels like a lot happened with the Commanders. First off, I think QB Sam Howell is in a great spot to learn and develop this year with mentors like Jacoby Brissett and then his OC Eric Bieniemy. They will hold him accountable like has already been happening and help bring out the best in him. Now it definitely is an organization surrounded by distractions. First off the trademark application for the team’s name was denied and they hope to get something figured out but could lead to another name change. Also, the team is still working through the Josh Harris bid and there need to be some adjustments in order for it to get accepted by the other NFL Owners and the league. These distractions even though they may not always be good for the team they probably do help a young quarterback because he is not the only thing to talk about at this point in the offseason.
Miscellaneous/Other NFL News:

• Many believe that Thursday Night Flexing is to cater to Amazon but really could be the future of how deals get done
  
  • Teams have to have 28 days notice and this is currently just a 1 year move
• RB Jeremy Hill who has not played for the past 5 seasons officially retired siting injury issues leading to his retirement
  
• NFL injury data shows that turf fields are significantly worse for players than grass fields
  
• The Pat McAfee Show will be taking over Max Kellerman’s the time slot on ESPN
  
• Commissioner Roger Goodell’s lobbying convinced teams to vote in favor of the new kickoff rules
  
• Dr. Timoth Kremchek, the Cincinnati Reds' physician since 1996, says he sees an "epidemic" of youth injuries on artificial turf
  
• RB Adrian Peterson will be hanging it up if he’s not back in the NFL this season
  
• After Goodell’s retirement the NFL could change the structure of management for the NFL combining a traditional CEO with a Commissioner of Football
  
• Possible a team will play 3 back to back games in Europe in the future
  
• Devin McCourty will be joining NBC’s Sunday Night Football crew as an analyst
  
• Officially approved emergency 3rd QB rule
  
• Investigating further violations potentially of league gambling policy
  
• DirecTV will still distribute Sunday Ticket to bars and restaurants
  
• S Tony Jefferson announced his retirement
  
• Announced growth of global market program
  

​
Restaurant of the Week: (Washington D.C. - TACOS 5 DE MAYO)
Don’t really have a great picture of this place but that may be a good thing. Often times I find that the places least advertised and that are holes in the wall is typically where you get the best Mexican food. This place is about a 10 minute drive from the stadium and probably closer to 15-20 minutes on game days depending on the time you go. Personally I recommend the Tacos Al Pastor. Those are basically a marinated pork taco that is slightly spicy with some sweet pineapple flavor in it. You cannot go wrong with Tacos Al Pastor and are by far my favorite. The other thing to keep an eye on is the Pupusas. While Pupusas are from El Salvador this place actually does a pretty dang good job of making them. For those that don’t know what Pupusas are they kind of resemble a stuffed pancake but are made of corn in most cases stuffed with either just cheese, cheese and beans, or cheese and pork. My order here would be 3 tacos al pastor and a cheese and bean pupusa. Enjoy!

The global airway management devices market size was valued at USD 1.81 billion in 2021 and is projected to reach a valuation of USD 1.89 billion in 2022. The market is expected to reach USD 2.55 billion by 2029 with a CAGR of 4.4% during the forecast period. Owing to rising cases of chronic diseases such as chronic obstructive pulmonary disease (COPD), cancer, chronic lung diseases, and others have put emphasis on better treatment of such conditions. Rising number of joint ventures and start-ups is projected to aid market development. Fortune Business Insights™ shares this information in its report titled “Airway Management Devices Market, 2022-2029.”
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https://www.fortunebusinessinsights.com/enquiry/sample/airway-management-devices-market-107396
Key Industry Development
​

• January 2022- Intersurgical Ltd announced the acquisition of Pulmodyne, Inc. to provide Intersurgical and for increased sales of the Pulmodyne ranges through the extensive global Intersurgical Ltd network.

Drivers and Restraints
Rising Number of Joint Ventures and Startups To Propel The Demand For Product
Rising number of joint ventures and startups in the industry are anticipated to drive the airway management devices market growth. Number of market players have been focusing on producing airway devices which are technologically advanced along with development of new R&D centers. Additionally, rising production by key players and approval from regulatory bodies for low-cost devices is expected to boost market growth. In April 2021, Medtronic launched the largest R&D center in India to launch new devices, advancing new technologies in surgical navigation and imaging, airway devices, ventilators, and many others.
However, complications such as regurgitation and aspiration of gastric contents, compression of vascular structures, trauma and nerve injury are expected to limit the market growth.
COVID-19 Impact:
Postponements of Non-Essential Surgeries During Pandemic Led to Decline in the Market Progress
The COVID-19 pandemic led to the decline in market growth for airway management devices in 2020. Various countries across faced challenges in accessing medical care and treatment due to postponements & de-prioritization of non-essential surgeries. In 2021, according to Centers for Disease Control and Prevention (CDC), the U.S. emergency department (ED) visits declined by 42% from for some time in 2020, after the declaration of a national emergency for COVID-19 pandemic. As per the estimates, ED visits from December 2020 to January 2021 were 25% lower than during the same months in 2019.
Segmentation
Infraglottic Devices To Lead With Rise in Chronic Respiratory Disorders
On the basis of type, the market is divided into infraglottic devices, supraglottic devices, laryngoscopes, and others. Infraglottic devices held the largest share in the year 2021 due to rise in the chronic respiratory disorders and adoption of such devices by healthcare providers in intensive care units.
Click here to get the short-term and long-term impact of COVID-19 on this market.
Please visit: https://www.fortunebusinessinsights.com/airway-management-devices-market-107396
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Fortune Business Insights™ delivers accurate data and innovative corporate analysis, helping organizations of all sizes make appropriate decisions. We tailor novel solutions for our clients, assisting them to address various challenges distinct to their businesses. Our aim is to empower them with holistic market intelligence, providing a granular overview of the market they are operating in.
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Aromatase inhibitors (AIs) are commonly used in the treatment of hormone receptor-positive early breast cancer. However, musculoskeletal symptoms, such as joint pain, stiffness, and bone loss, can be a significant side effect of AI therapy. These symptoms can impact patients' quality of life and adherence to treatment. Here are some systemic therapies that have been explored for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms:
​

1. Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs, such as ibuprofen and naproxen, are commonly used to relieve pain and reduce inflammation. They can be effective in managing AI-induced musculoskeletal symptoms. However, long-term use of NSAIDs may have gastrointestinal and cardiovascular side effects, so their use should be discussed with a healthcare provider.
2. Bisphosphonates: Bisphosphonates, such as zoledronic acid and pamidronate, are medications primarily used to prevent bone loss and treat osteoporosis. They have been studied as a preventive strategy for AI-induced bone loss and associated musculoskeletal symptoms. Bisphosphonates can help maintain bone density and reduce the risk of fractures in women receiving AI therapy.
3. Selective estrogen receptor modulators (SERMs): SERMs, such as tamoxifen and raloxifene, are hormonal therapies used in the treatment and prevention of breast cancer. They can have positive effects on bone density and may help alleviate musculoskeletal symptoms associated with AIs. However, their use may depend on factors such as menopausal status and the risk of breast cancer recurrence.
4. Denosumab: Denosumab is a monoclonal antibody that inhibits the activity of cells responsible for bone breakdown. It is approved for the treatment of osteoporosis and has shown efficacy in preventing AI-induced bone loss and reducing musculoskeletal symptoms. Denosumab is administered as a subcutaneous injection.
5. Vitamin D and calcium supplementation: Adequate levels of vitamin D and calcium are important for maintaining bone health. Supplementation with vitamin D and calcium may be recommended to prevent AI-induced bone loss and alleviate associated musculoskeletal symptoms.

It's important to note that the choice of therapy may depend on several factors, including individual patient characteristics, treatment goals, and potential side effects. The decision to use these therapies should be made in consultation with a healthcare provider who can assess the patient's specific needs and consider the available evidence and guidelines.
more information for this article visits site: https://freebreastcancerguide.com/

Cervical cancer is a type of cancer that develops in the cells of the cervix, which is the lower part of the uterus. It is one of the most common types of cancer affecting women worldwide. Understanding the symptoms and types of cervical cancer is crucial for early detection and effective treatment.
Symptoms of cervical cancer may vary, and in the early stages, there may be no noticeable signs. However, as the disease progresses, common symptoms can include abnormal vaginal bleeding, such as bleeding between periods, after sexual intercourse, or after menopause. Additionally, women may experience pelvic pain, pain during intercourse, and an increase in vaginal discharge.
Cervical cancer can be classified into two main types: squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma arises from the thin, flat cells that cover the surface of the cervix, while adenocarcinoma develops from the glandular cells lining the cervical canal. It is also possible to have a combination of both types.
Risk factors for developing cervical cancer include infection with high-risk types of the human papillomavirus (HPV), a weakened immune system, smoking, long-term use of hormonal contraceptives, multiple sexual partners, and a family history of cervical cancer.
Regular screenings, such as Pap smears or HPV tests, are vital for early detection and prevention. Women aged 21 and older are recommended to have regular Pap smears to detect any abnormal changes in cervical cells. HPV vaccination is also available to protect against the high-risk strains of HPV that can lead to cervical cancer.
If cervical cancer is suspected, further diagnostic tests, such as a colposcopy, biopsy, or imaging scans, may be performed to confirm the diagnosis and determine the stage of the cancer.
Early-stage cervical cancer is highly treatable, often involving surgery to remove the cancerous tissue. Advanced stages may require a combination of treatments, including radiation therapy, chemotherapy, and targeted drug therapy.
Education and awareness about cervical cancer symptoms and types are crucial for women's health. Regular screenings, vaccination, and adopting a healthy lifestyle can significantly reduce the risk of developing cervical cancer and improve overall well-being. It is important for women to consult with their healthcare providers for guidance on screenings, prevention, and early detection of cervical cancer.

This channel holds podcast-style interviews with various experts on various topics -- but this one struck me as especially Kraut-like in its analysis. The interviewee describes how the British financial system (unwittingly) enabled the deterioration of Russian society and continues to (unwittingly) obstruct democratic development around the world.
I recommend watching the whole thing. To entice you, I've transcribed some juicy quotes below.
https://www.youtube.com/watch?v=Yck3rYN-GbE
[2:56] [Londongrad] is a catchy term [but] I do have a slight problem with it, because it stresses the role London plays in laundering money for the former Soviet Union when actually London is not nearly so specialized in the service it offers. [...] It launders money from absolutely anywhere. In fact, the money from Russia or Eastern Europe is a relatively small subset of the money that pours through the City of London.
[5:20] When communism ended in Russia in 1991, a reforming government came to power. Boris Yeltsin was then president, and appeared to be (in his erratic way) sincerely committed to build a new system. [...] A particular concern of the government at the time was: how do you prevent the Communists coming back to power in the next election? How do you establish democracy irreversibly? They had a plan: [...] use private property as the tool to build democracy in Russia. [...] If they could establish a class of property owners, those property owners would then demand protection from the courts to prevent it being taken away [then] they would demand laws in those courts and then they would demand that those laws be created in a fair manner, which would require a functioning legislature, which required functioning elections, and that required all the paraphernalia around elections. So, in this way, there is a logical chain which leads from "rapid privatization" to "free and fair elections".
[8:32] The problem with this plan is that it never had the chance of being implemented [because] the winners from the very early privatization auctions -- the people who got very rich in the 1990s -- managed to take the money out of Russia and putting it into London. So they didn't need rule of law in Russia, they didn't need democratic elections, they didn't need free and fair courts... because they could buy all that in London. [...] Instead of the oligarchs (as we now call them) being a temporary problem -- a necessary evil for building democracy and freedom in Russia -- they became [...] a colonizing class in their own country.
[10:14] London wasn't alone in the 1990s. Much of this money also flowed to Switzerland and New York, but in both of those cases there were serious investigations [...] which helped to limit the money flow. There was no equivalent in London.
[10:56] This has created a form of political economy which is unique among large countries, where [...] more than half of national wealth is housed outside Russia. The equivalent for European countries is about 10% and in the United States it's 5 or 4. Fifty-one percent of national wealth is outside Russia.
[12:03] That's kind of our fault. [...] How did Putin build the kleptocratic system, how did the oligarchs manage to steal everything? Because we helped them. We provided the legal services, the accounting services, we sold them property, we educated their children, we sold them fine art, we kept their superyachts, we provided them with taxation systems, we sold them golden visas, we helped them sue journalists who tried to write the truth about all this.
[13:36] We are stepping in to try and help the Ukrainians solve a problem that we caused.
[15:30] I've never got any sense that this was a deliberate policy. It's something that was profitable, and therefore no one was in the mood to ask too many questions. [...] There was a self-serving ideology -- which is not uniquely British, we see the same in Germany and other European countries -- that by trading with the Russians we would be civilizing them. [...] The idea that "what I want to do anyway, which is make money from these people, is not just good for me but good for everybody" is an incredibly convenient philosophy.
[21:25] There was an astonishing alliance between the Soviet Union -- specifically, its state bank Moscow Narodny Bank which was based in London -- and the Midland Bank [...] This was in the 1950s: the MNB decided to lend its dollars to Midland Bank and thereby discovered that if you use dollars in London, all the restrictions disappeared. [...] Before too long, it wasn't just Midland Bank doing it, but all the London banks, then other banks opened branches too: American banks, German, Japanese, French and so on. This was the birth of offshore finance [...] liberating the wealthy from the control of the rest of us.
[25:43] This willingness to profit from anybody is at the core of the reinvention of London from the capital of the British Empire to the capital of the Offshore Empire. That's why I refer to them as "butlers to the world".
[28:17] It's very difficult to pin down precise numbers, but it's clear that Russia is more unequal than it was on the eve of the first world war. The oligarchs now have a greater proportion of wealth than the aristocrats did under the tsar.
[30:46] There was a sense in Russia that the Europeans were incapable of uniting against the Russian threat, so it came as a shock in Feb '22 when that's precisely what happened. The UK, the EU, the US, Canada, Australia, Japan [...] paralyzed the mechanisms by which Russian oligarchs operated [...] so they've been seeking new mechanisms to get their money out of Russia. [...] Turkey has stepped in, and of course Dubai, which has a perpetual role in helping corrupt people get money out of their home countries.
[32:02] But that is only because of sanctions, and sanctions are a foreign policy tool. [...] There hasn't been in the UK -- or any other European country -- an adequate law enforcement response. [...] There's been a little work in the US and Canada, but very little done in this country, and that's a result of [our] disastrously underfunded law enforcement agencies.
[37:34] Ukraine, as people ceaselessly remind you, was (and probably is, in many ways) as corrupt as Russia [...] but what it doesn't have is a pyramid of corruption with one person at the top [...] Instead you have multiple warring clans [...] and in the cracks between these clans a civil society was able to appear in Ukraine. [...] In this pluralistic corruption, Ukraine was able to build this vibrant, powerful, horizontally organized society which is very different from the vertically organized Russian society.
[45:33] How do you de-radicalize someone like Putin? [...] I think that the only solution now is for him to lose, and sadly that will involve tens of thousands of young men's lives [...] because of the system that the oligarchs allowed him to create and the system that we in the UK allowed them to create. [...] That is a serious thing that we need to recognize and address, because [...] all the other kleptocrats are still bringing their wealth here: Chinese, Malaysian, Nigerian, whatever, it flows here uninterrupted. [...] This is an opportunity for us to examine what we've done [...] and make sure it never happens again.
[48:00] London as an offshore market is unrivaled. [...] You can get private school for your children in Switzerland, you can build opaque corporate structures in Dubai, but everything together in one place, the world-class financial system, the world-class legal system, a generous tax system, a huge art and luxury goods market, coupled with a network of tax havens -- no one else comes close. If London stopped being a center for kleptocratic wealth, it would destroy the global money-laundering system.
[52:04] Economics is not maths. You don't have to agree to it. The reason R has been greater than G over the centuries is because the rich have been able to capture politics. [...] We can fight back against that.

"The reason vaccinations are promoted with such intensity is to prevent people from realising that vaccines do not protect and also in the event of an outbreak or an epidemic the vaccinated are as much at risk of becoming infected as the unvaccinated. The truth can be kept hidden if people's vaccination status remains unknown and if everyone is vaccinated, making a comparison with unvaccinated people impossible. This is also the real reason for the relentless push to vaccinate as many children as possible." -Dr. Gerhard Buchwald, MD The Decline of Tuberculosis despite "Protective" Vaccination p.101

"The reason vaccinations are promoted with such intensity is to prevent people from realising that vaccines do not protect and also in the event of an outbreak or an epidemic the vaccinated are as much at risk of becoming infected as the unvaccinated. The truth can be kept hidden if people's vaccination status remains unknown and if everyone is vaccinated, making a comparison with unvaccinated people impossible. This is also the real reason for the relentless push to vaccinate as many children as possible." -Dr. Gerhard Buchwald, MD The Decline of Tuberculosis despite "Protective" Vaccination p.101

This is Part 2 because of the character limit, go here to get caught up: https://www.reddit.com/TheDarkGathering/comments/13urkbj/the_thing_in_the_cracks_part_1/
Talbot awoke in a round corridor. At least he thought that’s what it was. The corridor seemed to be made of dark stone, rough and ridged like a worm’s tunnel, but on a massive scale. Despite no visible light source, Talbot found he could make out every detail in the space around him.
Talbot shakily stood up and considered his situation. His hands were shaking. He supposed nearly getting killed by lethal injection and then shattering the very fabric of reality itself took a toll on the psyche. He reflexively reached for his notebook to note that down, and with a pang remembered that it was gone. He would likely never see it again.
Glancing around, Talbot wondered at how normal everything looked, considering he was in the fifth dimension. There was likely more going on under the surface, but from his vantage it just looked like an oddly lit cave.
Talbot noted that there was no sign of Willis. He’d distinctly remembered the other man getting pulled through time and space with him, but at some point during the traversal his hand had been wrenched away from Talbot’s wrist. Had he been shunted back to their reality, or was he here somewhere?
A deep rumble began to grow beneath Talbot’s feet. The entire cave shook like an earthquake as Talbot scrambled to the side of the tube.
Confused, the man glanced around. He saw no probable cause for the rumbling, no subterranean vehicles or even geological fissures that could explain the vibrations.
Turning, he realized with a start that the rumbling was slightly stronger on one side of him. If it was directional, there was an actual source, not just a general shaking of the environment.
Talbot began moving away from the rumbling, as it continued to grow stronger.
Eventually, he broke into a full run as everything around him shook. He felt like his skull was going to burst. It felt like something was chasing him, a massive subterranean beast.
As the rumbling kept growing, Talbot tripped. Out of nowhere, his foot slipped and he sprawled to the ground, crying out as he landed on his arm. He tried to get back up, which was when he realized there was something right behind him.
Talbot hit the deck, right as something zoomed directly above his head. Wind pulled at his hair and it felt like he was directly under a train.
Talbot screamed, but it was drowned out by the impossibly loud whoosh of the thing above him. He gingerly flipped onto his back, barely staying clear of the surface of whatever was making the sound, in order to see what was above him.
There was nothing but empty space.
Then, he could suddenly see a long gray tube rushing past impossibly quickly. Then it was gone again, but the rushing was still there. It was blinking in and out of existence, only appearing for short bursts, but still there in its invisible state. Talbot realized that it must be dipping in and out of the Fifth Dimension, his own limited perception unable to comprehend its greater state.
Eventually, the thing slowed and stopped. As it was still, Talbot got a better look at it.
It was definitely organic. The exterior of the tube had a pale gray color, with a texture not unlike skin. However, as opposed to the neat, even lines separating cells on human skin, the striations on the thing seemed almost random, forming a surface that, although smooth, had the jagged impression of rough crags.
As Talbot examined the thing and wished he’d brought a camera, he heard something. From the object’s direction of origin, a deep groan emanated from lord-knew-where. Talbot winced as it hit his ears, the bellow deafening. He could immediately detect three things about the cry, judging by the cadence and the way it had slowly grown from an origin point. First, it definitely came from a living thing. Nothing artificial made that noise. Second, it came from very far away. And thirdly, it came from something massive. Impossibly so.
From the other direction, so comparably quiet he barely heard, Talbot made out a shriek that was horribly human.
The thing above him shifted and despite having almost a foot of clearance, Talbot instinctively sucked in his gut.
The tube… the limb began moving in the opposite direction, back towards its origin point.
Like a train, it started slowly but accelerated quickly, beginning to blink in and out of Talbot’s vision once again.
Talbot heard the scream again, closer this time. It seemed likely that whatever this thing was had found and grabbed another person.
After several long moments, the end of the limb finally reached Talbot, shooting past and above him like a tape measure shooting back into its shell when a button was pressed.
After it passed, Talbot sprang to his feet and finally got a good look at the end of the thing’s limb. The actual tube rounded off, dispelling any predictions about a monstrous tentacle. However, what was on the end of the limb may’ve been even more horrible.
Four long finger-like appendages were arranged around the limb radially, each one emerging from the edge of the flat tendril end. They were unnaturally thin, and despite somewhat resembling fingers, they had no visible knuckles and were tipped with sharp claws that appeared to be made of bone. They bent in, each holding their prey in place. Their prey in question was Tim Willis, currently pulling against the monstrous cage. The four outer digits pressed on each of his limbs, drawing blood where they poked him.
The limb, and Willis with it, disappeared around a bend in the tunnel. Talbot ran after it. He wasn’t sure what he was going to do, or if he was going to save the man, but he knew that no matter what happened, he wanted to see it.
For a long while Talbot chased the thing, barely keeping pace due to his cardio experience. During the run, whatever existed here continued bellowing, getting louder each time. In addition, each time he set his foot down, the ground felt slightly warmer.
Eventually he fell back, and lost sight of the thing completely. It was impressive that a man of his age and lifestyle had managed to follow the thing for so long, but he had to take a knee as exhaustion racked him. He continued following its path, but at a slower pace.
Eventually Talbot emerged into a much larger chamber. The air here was blistering, and the intermittent bellows had grown so loud that Talbot had to cover his ears every few minutes to keep from suffering permanent damage.
This cavern left him speechless.
Unlike the passage, with its unidentifiable neutral lighting, this cavern was dark, intermittently lit by what appeared to be giant glowworms, each perched on a rock surface and oozing an ugly orange aura into the space around it.
Less than half of the room was lit, but it was enough for Talbot to see that the remaining more-than-half was taken up by a monstrous… thing the same shade as the limb.
It was like a spider, in the same way that a massive dragonfish from the bottom of the sea is like a goldfish. Its main body was shaped like a blimp, and about the size of one too. A large abdomen sagged beneath it as it hung in the exact center of the room, and eight radially symmetrical limbs stuck to eight points around the cavern, suspending it in the middle of the room, and making it look like the center of a giant wheel, each limb serving as the spokes.
This facsimile was somewhat broken by the auxiliary limbs attached to its thorax, countless smaller tendrils identical to the one that held Willis. Some hovered around the thing’s ‘face’, while others darted towards countless holes in the rock around the cavern. As they moved, they blinked in and out of Talbot’s vision as they tapped into primordial forces beyond his eyes.
The cavern was dotted with holes, all exactly the same size and shape as the one Talbot stood in the lip of now. He realized that this thing and its countless appendages must’ve bored into the stone around it, creating a labyrinthine lair not dissimilar to an ant’s hive, but with one crucial difference. Rather than hundreds of tiny workers, this entire place had been built by, and for, one monstrous being.
Talbot was so stunned by the beast that he didn’t notice one of its many tendrils coming straight for him.
It appeared directly in front of his face, resulting in a jumpscare that sent him tumbling backwards, falling onto his back.
The thing moved like a snake, if a snake was constantly flipping between visible and invisible.
It struck, speeding downwards towards the chemist. Talbot braced for impact, but just before it could hit him it disappeared.
Talbot sat relieved, as it had apparently teleported somewhere else.
That was until it reappeared with the fingers around his torso.
The tendril had re-manifested just past him, the fingers clipping partway into the floor as they cradled him. Talbot felt four small pricks in his back and the backs of his thighs, where the claws had pierced his flesh.
The thing pulled him upwards, the fingers embedded in the ground breaking out of the stone beneath him and sending chunks of rock several feet in all directions.
The tendril shot up towards the ceiling of the cavern, rising what must’ve been 60 feet in half a second. Talbot could barely see the ground around the tendril, far enough below to dizzy him.
Talbot saw stars.
Talbot wished he could see the stars.
The tendril took him, in a daze, towards the thing’s face. As Talbot grew closer, he heard a ragged hissing, like an oxygen tank leaking. He realized it was the monster breathing, but immediately was unsure once its head turned toward him.
Its head was roughly human-shaped, but utterly inhuman in every other way. Five dark pits, facsimiles of eyes, were arranged in a pentagonal shape on the top half of its face. The bottom half was flat skin, but flat skin that seemed to be vertically stretched, as though it’d been draped over some opening. That was possibly where the breathing was coming from, but there was no way to tell with no actually apparent orifice.
The thing seemed to sniff Talbot, despite having no nose. Then it turned, and brought another piece of potential food to its head.
With a start, Talbot realized Willis was still alive. Or at least, unconsumed. He hung limp from his tendril, held in place by the finger-things and seemingly unconscious.
But the Thing wasn’t interested in either of them, not yet at least. It brought one of its tendrils up to its head before plunging it directly toward a nearby rock face. Right before it made contact, it disappeared.
Talbot reached towards Willis, but he was just outside of his reach. He didn’t want to yell to the man. The thing had no ears, but there was no guarantee that it couldn’t hear somehow.
The tendril that the thing had sent away reappeared, seemingly partially buried in the rock face. The thing wrenched its tendril from the rock, leaving behind a shallow pockmark in the cave.
Skewered on the spine was a small man. He flailed wildly and screamed something in a language Talbot didn’t know. He was wearing a business suit, but his pants were around his ankles, with baby blue boxers underneath.
Talbot wondered where he’d come from, then realized with a start that he’d likely originated from the real world. Meaning that this thing could reach beyond this reality and into their reality. Oh shit. Maybe he should’ve listened to Talc. If he and Willis hadn’t breached the Fifth Dimension, maybe the thing couldn’t’ve done the same, and this man might still be safe out there.
The thing brought the man towards its face and did the strange sniffing motion again. Satisfied, it brought him even closer. Talbot, despite himself, was curious to see how it consumed prey, and so paused in his attempts to wake Willis in order to watch.
The man screamed as the tendril brought him right up to the thing’s face, and then the thing’s face disappeared, moving through the Fifth Dimension in the same way as its tendrils.
When it reappeared, it was halfway inside the man, the smooth layer of skin clipped through his abdomen.
The thing pulled its head back.
Talbot turned away as a bloodcurdling scream and a terrible ripping sound reverberated through the cavern. He reached for Willis again, and to his surprise, found that he could reach him. He tapped him on the shoulder, and when he got no response, he slapped him in the face. Willis stirred, and slowly opened his eyes. He put a hand to his face and frowned. “Ow,” he said quietly.
Talbot put a finger to his lips and indicated the beast’s head with his eyes, and the gruesome consumption of the poor man.
Willis seemed to get the message. He quietly started prying each finger off of his body, praying that the thing had no nerves in the spines.
Talbot turned back towards the creature, which had repeated the teleportation maneuver a few more times before finally swallowing what remained of the man. Seemingly not quite satiated, Talbot’s tendril began to move as it pulled him closer to its face.
Talbot’s eyes widened and he looked back at Willis in fear. The man made a motion that suggested Talbot should try to stay calm, and that Willis would be along as soon as he’d freed himself.
Talbot tensed as he was pulled along, not wanting to be brought any closer to the monster. The thing brought him up to its face, and seemed to study him with the light-sensitive divots in its face. Talbot glanced back at Willis to see that he’d moved 2 of 4 fingers out of place. The larger man shot him a reassuring nod.
Turning back to the monster, Talbot realized that the other man wouldn’t get here in time. The thing was already lunging its head forward, and it blinked away.
It reappeared with Talbot’s shins inside its face. Behind the skin, Talbot’s feet could feel a damp cavity, so there was presumably a mouth of some sort behind the surface, and it wasn’t just solid flesh. A row of teeth closed around his legs, but not hard. They worked more to keep him in place than to actually damage his legs.
Talbot took a second to wonder why the hell he was considering the consumption mechanics of something that was actively chopping off his legs.
The tendril moved backwards, pulling Talbot away from the thing.
These last few lucid seconds, Talbot’s brain reverted to factory reset settings. Instead of hearing the wet tear of both his legs, or the strangely cartoonish wet pop as the bones in both his shins were yanked away from his kneecaps, he found himself focusing on the strangest things.
Talbot considered the glowworms. Were they native to the Fifth Dimension, or had they come here from his, or another, Earth? If they were native, the convergent evolution with Earth glowworms, especially in an environment so alien, was coincidental to an unfathomable degree. If they had originated from Earth, however, why the orange glow? No glow worms on Earth glowed orange. Also, if they were Earthly, why did the thing not eat them? Did it only eat humans? Was it that cunning? That cruel?
Oh, Talbot realized, I’m falling.
He blacked out before hitting the ground.
Talbot’s first thought upon waking up was, Holy shit, I’m still alive. His second thought was, Holy shit, how the hell am I still alive?
His inner ear told him he was prone, but it’d been on the fritz ever since he’d arrived, so he opened his eyes to make sure. They confirmed what his ear was saying, and he took a quick second to thank all his organs for functioning so well under stress.
Willis sat next to him, notably more intact. He was wearing no shirt, and both his abdomen wound and Talbot’s stubs were bound in the fabric of an Anderson Innovations janitor’s uniform.
Talbot started staring at his abs, which caused Willis to glance down at him.
The other man cleared his throat. “Oh, you’re still alive?”
Talbot nodded softly. “Does it not know where we are?”
“Not yet,” Willis shrugged, “It has no eyes and didn’t see us escape, so it’s sending out tendrils through each passage, and hasn’t picked this one yet. I guess we got lucky when I dragged you in here.”
“Yeah. Why is that, by the way? You were just about to kill me before I trapped you in a hellish cave dimension.” He considered his words. “Which would only be more reason to kill me.”
Willis shook his head and chuckled tiredly. “Call me an idealist, but I didn’t join a group called the Agency for the Preservation of Humanity to kill people. I’m not good at holding grudges.”
“Then why were you gonna kill me when we were still out there?”
“It’s different. I had orders. Now Talc isn’t here, so it’s my decision. The real question is how are you still alive even with my intervention?”
Talbot shrugged, which made him dizzy. “ I’m on my way out. That blood loss will kill me in a couple minutes, if that thing doesn’t find us first.”
Talbot glanced around the environment for the first time, and realized they were once again in one of the small side tubes. Loud bellowing filled the air as the thing presumably scoured its domain for the two men.
“Well, at least our sacrifice will save the rest of humanity.” Willis proclaimed.
Talbot chortled.
“What?” Willis responded.
“Didn’t you see the other guy get eaten?”
“What?! There was another guy?!”
“Yeah, it stole him from our world.”
“Goddammit Talbot, Talc said that would happen!”
“Yeah, sorry about that.” Talbot said, in a tone that didn’t sound very sorry.
“At least it was just once. Talc has your notes, so he’ll keep it from happening again.”
Talbot almost guffawed.
“Goddammit, what am I doing that’s so funny?!”
“No, it’s not you. Well, it is you, a little, but it’s mostly the fact that I… may’ve doomed humanity anyway.”
Willis was silent, which Talbot regrettably took as a prompt to continue.
“Cause you see,” the scientist slurred, getting more light-headed by the second, “before I tried to ship off the notebook to Johnson, I ripped out the most important parts and sent ‘em to Vincent Anderson, my boss.”
Willis remained silent.
“So, you know. Hopefully someone publishes that in a journal somewhere so that people can actually remember me.”
Willis punched him in the face, hard.
Once he recovered, Talbot nodded. Blood ran from his nose. “I deserved that. I’m sorry, I didn’t know that learning how to break reality would allow a Great Old One to start eating people.”
Willis shook his head in disgust. “Talc told you not to. Do you really think your legacy is more important than the survival of our species?”
Talbot didn’t respond. Whether it was because he was speechless or dead was unclear, and didn’t really matter in any case.
Willis turned and limped away.
Two days after Willis and Talbot disappeared to the Fifth Dimension, Talc said goodbye to… himself and Willis-2, and used a Seal of Traversal to return to his native dimension. He reported to his boss that Willis was gone and would not be returning, before going to Talbot’s house and opening the door with the key they’d taken from the scientist.
Talc went into Talbot’s kitchen and fetched a can of tuna and a jar of mayonnaise. He mixed the two together and filled the pet bowl on the counter. Noting that there was some left, he made himself a tuna sandwich and sat next to the bowl.
It took Ozymandius a while to approach Talc, and even longer to warm up to him. However, the cat was curled up against the delicate man, purring like an engine, by the time the sunset rolled around and they both watched it out the large windows at the back of Talbot’s house.
Talc’s phone rang.
“Yello?” Talc said to the unknown caller.
“Hey.”
Talc immediately tensed. The voice was, undeniably, Talbot’s.
“What is this?!? Where are you?!?”
When the Talcs and Willis had reviewed the CCTV footage, they’d realized exactly where Talbot and Willis had ended up, and had naturally concluded that they were dead.
“I honestly don’t know. I was just in the Fifth Dimension with Willis, but now I’m unsure. It’s dark, and my legs don’t hurt anymore.”
“What does that mean?! Are you still alive?! Is Willis still alive?!”
“I don’t think so. I think I’m dying. Already dead?”
“Then how are you talking to me? Are there phones in the fifth dimension?”
“Nah, I can just hear you. My hypotheses are that this is either a feverish hallucination in my dying moments, or that the Fifth Dimension can somehow…” Talbot’s speech sank into bleary muttering, and was unintelligible for several words. “...subsurface conduit.”
“Talbot, you’re delirious. That makes no sense.”
“Good, so it’s the other hypothesis. Just cause I know you won’t actually hear this, take care of my cat.”
Talc moved to speak, but Talbot continued.
“Oh also,” He added, almost as an afterthought, “I sent my notebook to Anderson, so watch out with that.”
“Wait what, excuse me?!”
The line went dead.
Talc heard a thunderous snapping sound. He whirled around to face the window, pressing his face against the glass and staring up at the sky.
A horrific ripping sound filled the air as the very fabric of the Fourth Dimension was rent apart, the sky above Talc yawning wide. The thing’s tendrils emerged from the rift in the atmosphere and descended towards the ground, each one darting around erratically as though tasting the air.
Talc did not know what Talbot, or Anderson, or whoever had done, but he knew that they had forever changed the world around them, and doomed a large portion of the human race.
You haven’t just opened Pandora’s box, you fool, Talc thought bitterly of the foolish chemist, You’ve blasted it apart with plastic explosives.
Talc returned to the couch and cradled Ozymandius. There was little to be done now.
Talc felt almost relieved that his decades-long vigil could finally come to an end.
The Cracks in the world had finally become holes, and through those holes came a flood.

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Introduction: In the bustling city of Ghatkopar, Mumbai, individuals seeking top-notch eye care services can rely on the expertise of Dr. Jatin Ashar. With extensive experience and specialized knowledge in the field of ophthalmology, Dr. Ashar has garnered a reputation as a trusted eye specialist. His clinic, located in Ghatkopar, offers a wide range of eye treatments and surgeries, including dry eye treatment. In this blog, we will explore Dr. Jatin Ashar's approach to dry eye treatment in Ghatkopar, highlighting his qualifications and the services he provides. Dr. Jatin Ashar: A Skilled Eye Specialist: Dr. Jatin Ashar, a highly skilled eye doctor, is the Director and Chief Operating Surgeon at Mumbai Eye Care Hospital in Ghatkopar, Mumbai. He is a specialist in cataract, cornea, and refractive surgery, holding an MD degree from AIIMS (All India Institute of Medical Sciences). Dr. Ashar is also a fellow of the prestigious L V Prasad Eye Institute, further attesting to his expertise in the field. With over 11 years of experience in ophthalmology, he has earned a reputation for his excellence and dedication to providing exceptional eye care.
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• Artificial Tears and Lubricants: Depending on the severity of dry eye syndrome, Dr. Ashar may recommend the use of preservative-free artificial tears and lubricating eye drops. These help in maintaining proper tear film hydration and reducing discomfort.
  
• Prescription Medications: In some instances, Dr. Ashar may prescribe medications such as anti-inflammatory eye drops or cyclosporine ophthalmic emulsion to reduce inflammation and stimulate tear production.
  
• Advanced Treatments: For severe cases of dry eye syndrome, Dr. Ashar may recommend advanced treatments such as autologous serum eye drops, punctual plugs to conserve tears, or specialized therapies like intense pulsed light (IPL) treatment or meibomian gland expression.
  

Conclusion: For individuals seeking effective dry eye treatment in Ghatkopar, Mumbai, Dr. Jatin Ashar's clinic offers a comprehensive range of services to address this condition. With his extensive experience, specialization in cataract, cornea, refractive surgery, and patient-centered approach, Dr. Ashar has established himself as a trusted eye specialist in Ghatkopar. Whether it's through lifestyle modifications, lubricating eye drops, or advanced treatments, Dr. Ashar aims to provide relief to patients suffering from dry eye syndrome. If you or someone you know is seeking professional dry eye treatment, consider scheduling a consultation with Dr. Jatin Ashar to experience his expertise firsthand.
Name: Mumbai Eye Care Address: 101/102, Sai Vaibhav CHS, Nr. Vikrant Circle, Ghatkopar (East), Mumbai-400077 Phone: +91-8451045934, 8451045935, 022-25066699 Website: www.mumbaieyecare.com Website: www.mumbaieyecarecornealasik.com

An interesting new study was published today in a top medical journal. It describes how a common and safe "liver drug" shuts the door on COVID before it can infect our cells. This is serious research, not fringe theories.
The "drug" is ursodeoxycholic acid (UDCA). What they do not mention is the strange situation where this is both a drug and a dietary supplement capsule -- and the dietary supplement is the more "active" form of the substance. UDCA is activated when bound with the amino acid taurine (and taurine itself helps protect the retina). When activated this way, UDCA is called TUDCA.
TUDCA is the active compound in bear bile, which was used in several traditional medical systems. Some people still refer to TUDCA as "bear bile."
Bile is produced in the liver and stored in the gall bladder. It functions as part of our digestive process. Bear bile used to be extracted from Asian black bears. The harvest of bear bile was extremely controversial to say the least. Thankfully, it is no longer taken from bears, but synthesized in an ethical and sustainable manner. The main ingredients of bear bile are ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA), with TUDCA considered the activated form.
TUDCA is an oral dietary supplement that has been of interest to many glaucoma patients for a long time. Douglas Rhee, MD, wrote a section on it for a consensus paper for a major glaucoma organization more than a dozen years ago. In fact TUDCA (or bear bile) has a history of use for improving vision going back thousands of years in traditional Chinese medicine (Cidian 2004; Ventura 2009).
I'll explain more about TUDCA and the neuroprotection it may offer for the optic nerve below. But first, here is the abstract from today's newly published study in the prestigious journal Nature.
Abstract
Prevention of SARS-CoV-2 infection through the modulation of viral host receptors, such as ACE21, could represent a new chemoprophylactic approach for COVID-19 complementing vaccination2,3. However, the mechanisms controlling ACE2 expression remain elusive.
Here, we identify the farnesoid X receptor (FXR) as a direct regulator of ACE2 transcription in multiple COVID19-affected tissues, including the gastrointestinal and respiratory systems.
We then use the over-the-counter compound z-guggulsterone (ZGG) and the off-patent drug ursodeoxycholic acid (UDCA) to reduce FXR signalling and downregulate ACE2 in human lung, cholangiocyte and intestinal organoids and in the corresponding tissues in mice and hamsters.
We demonstrate that UDCA-mediated ACE2 downregulation reduces susceptibility to SARS-CoV-2 infection in vitro, in vivo and in human lungs and livers perfused ex situ.
Furthermore, we illustrate that UDCA reduces ACE2 expression in the nasal epithelium in humans.
Finally, we identify a correlation between UDCA treatment and positive clinical outcomes following SARS-CoV-2 infection using retrospective registry data, and confirm these findings in an independent validation cohort of liver transplant recipients.
In conclusion, we identify a novel function of FXR in controlling ACE2 expression and provide evidence that modulation of this pathway could be beneficial for reducing SARS-CoV-2 infection, paving the road for future clinical trials. [end of abstract]
Turning our attention to TUDCA's neuroprotective properties, here is a small sample of scientific studies available from PubMed:
Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases - PubMed

In recent years, hydrophilic bile acids, particularly tauroursodeoxycholic acid (TUDCA), have shown important anti-apoptotic and neuroprotective activities, with numerous experimental and clinical evidence suggesting their possible therapeutic use as disease-modifiers in neurodegenerative diseases.
Experimental evidence on the mechanisms underlying TUDCA's neuroprotective action derives from animal models of Alzheimer's disease, Parkinson's disease, Huntington's diseases, amyotrophic lateral sclerosis (ALS) and cerebral ischemia. Preclinical studies indicate that TUDCA exerts its effects not only by regulating and inhibiting the apoptotic cascade, but also by reducing oxidative stress, protecting the mitochondria, producing an anti-neuroinflammatory action, and acting as a chemical chaperone to maintain the stability and correct folding of proteins.
Furthermore, data from phase II clinical trials have shown TUDCA to be safe and a potential disease-modifier in ALS. ALS is the first neurodegenerative disease being treated with hydrophilic bile acids.

** TUDCA stands as a promising treatment for neurodegenerative diseases. **
The bile acid TUDCA and neurodegenerative disorders: An overview - PubMed

Bear bile has been used in Traditional Chinese Medicine for thousands of years due to its therapeutic potential and clinical applications. The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Several studies have shown that TUDCA has neuroprotective action in several models of neurodegenerative disorders (ND), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, based on its potent ability to inhibit apoptosis, attenuate oxidative stress, and reduce endoplasmic reticulum stress in different experimental models of these illnesses.
Our research extends the knowledge of the bile acid TUDCA actions in neurodegenerative disorders and the mechanisms and pathways involved in its cytoprotective effects on the brain, providing a novel perspective and opportunities for treatment of these diseases.

You can find many more interesting studies on TUDCA's neuroprotective potential.

• Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson's disease - PubMed
  
• Neuroprotective Effects of Tauroursodeoxicholic Acid Involves Vascular and Glial Changes in Retinitis Pigmentosa Model - PubMed
  
• Comparative Analysis of Urso- and Tauroursodeoxycholic Acid Neuroprotective Effects on Retinal Degeneration Models - PubMed
  
• Bile Acids as Key Modulators of the Brain-Gut-Microbiota Axis in Alzheimer's Disease - PubMed
  
• Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response - PubMed
  
• Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes - PubMed
  
• Co-delivery of glial cell-derived neurotrophic factor (GDNF) and tauroursodeoxycholic acid (TUDCA) from PLGA microspheres: potential combination therapy for retinal diseases - PubMed
  
• Oral Ursodeoxycholic Acid Crosses the Blood Retinal Barrier in Patients with Retinal Detachment and Protects Against Retinal Degeneration in an Ex Vivo Model - PubMed
  

TUDCA is non-prescription, relatively inexpensive and has a good safety record at doses up to 750 mg/day. If you decide to try it, be sure to buy it from a reputable company.